- Alpha Lipoic acid (ALA) and Glutathione (GSH) are both powerful antioxidants that aid in the reduction of oxidative stress caused by free radicals. Free radicals are unstable atoms created by the toxic byproducts of oxygen metabolism; they cause significant damage to living cells and tissues in a process called “oxidative stress.” Factors that have been known to cause free radicals are smoking, alcohol, air pollution and fried foods, but other processes as simple as aging and sun exposure can induce free radicals. ALA has been especially studied in patients with diabetes who are prone to nervous tissue destruction and its ability to protect nerve tissue.
Mechanism of Action / Benefits:
- Glutathione (GSH) is used as a cofactor in multiple peroxidase enzymes, which are enzymes that detoxify free radical attack on biological molecules
- GSH is also a cofactor in transhydrogenase’s which are enzymes that reduce oxidized centers on DNA, proteins, and other biomolecules.
- Studies have shown that GSH supplementation improves lipid metabolism and acidification in skeletal muscles caused by lactic acid buildup during exercise
- ALA is quickly absorbed and converted into dihydrolipoic acid (DHLA) by enzymatic action which is one of the most powerful antioxidants in our bodies and has received considerable attention for managing diabetic complications such as neuropathy, retinopathy and vascular disease.
- Lipoic acid is an essential cofactor for several mitochondrial multienzyme complexes that catalyze critical reactions related to the catabolism(breakdown) of amino acids and the production of energy
- ALA also acts as a metal chelator by binding free metal ions in our body that can induce oxidative damage. These free metal ions such as copper and iron contribute to neurodegenerative diseases and other chronic diseases
- ALA works synergistically with GSH by increasing concentrations of GSH in our cells as well as promoting GSH’s natural production pathways in our body.
- The recommended adult dosage for alpha lipoic acid is 200-800 mg per day
- The recommended adult intravenous dosage for glutathione is 600-1000mg/day
Potential Side Effects:
- Light-headedness / dizziness
- Increased flatulence
- Feeling jittery