Classification: FDA-approved Antiemetic ( anti-nausea )
- Zofran is often used in patients with nausea caused by surgery, chemotherapy, migraines, pregnancy or vomiting caused by an illness.
Mechanism of Action:
Zofran (Ondansetron) works by blocking the actions of chemicals in the body that trigger nausea and vomiting
- Zofran is a serotonin antagonist that blocks the serotonin 5-HT3 receptors in the chemoreceptor trigger zone (CTZ) within the medulla oblongata; the CTZ communicates with the vomiting center of our brain. Therefore, by blocking the amount of serotonin entering the CTZ, there is a decrease in communication and stimulation of the vomiting center, leading to decreased nausea and vomiting.
- The recommended adult intravenous dosage of Zofran is 0.15mg/kg up to a maximum of 16mg per dose. It is important to note that maximum dosages are reserved for patients undergoing chemotherapy or radiation treatments. Most post-operative nausea and vomiting as well as illness induced nausea is controlled with a dose of 4mg.
- The recommended adult intramuscular dosage of Zofran is a single dose of 4mg injected into either gluteus maximus.
Do not use if:
- Allergic to Ondansetron, Dolasetron (Anzemet), Granisetron (Kytril) or Palonosetron (Aloxi).
Tell your provider if you have a history of:
- Congestive heart failure
- Bradycardia (slow heart rate)
- Personal or family history of long QT syndrome
- Heart arrhythmias
- Currently on any psychotropic medications
Potential Side Effects: